Earlier work from our group showed that at fasting, plasma concentrations of total GLP-1 were elevated in children and adolescents with overweight and obesity compared with population-based controls, associating with insulin resistance, hyperglycemia, higher concentrations of plasma alanine transaminase (ALT), dyslipidemia, and hypertension (13, 14). The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.