Further support for the relationships found in the present study comes from adults in the IMI-DIRECT consortium (n = 726), which applied soft clustering of clinical phenotypes, exposing an archetype of obesity and insulin resistance associated with higher visceral fat and liver fat, lower physical activity, and higher fasting concentrations of glucagon and GLP-1 (44). This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.