Natural borneol can open the blood‐brain barrier and enhance the penetration of drugs into the brain.[24, 34] Wang and co‐workers confirmed that natural borneol monotherapy induced GBM cell apoptosis by regulating HIF1α expression.[35] Here, we demonstrate that sodium valproate combined with natural borneol prolonged the survival of tumor‐bearing mice and increased the VPA levels in xenografts (Figure 7L; Figure S7G, Supporting Information). Here, HIF1A is linked to glioblastoma.