Hypoxia promotes tumor growth and therapeutic resistance.[8, 26] The expression of TAGLN, a gene involved in hypoxic immunity, predicts a poor prognosis of gastric cancer.[27] HIFs promote GSC self‐renewal and tumor angiogenesis.[9, 28] HIF1α, but not HIF2α, regulated hypoxic induction of TAGLN expression (Figure 3A,B,G; Figure S3B, Supporting Information). The gene discussed is EPAS1; the disease is gastric cancer.