TARDBP and amyotrophic lateral sclerosis: Although aggregated trans‐active response DNA binding protein 43 kDa (TDP‐43) is the neuropathological hallmark in over 95% of ALS cases, a wide range of upstream pathways have been implicated in mediating neuronal death, including oxidative stress, excitotoxicity, mitochondrial dysfunction, impaired protein homeostasis, endoplasmic reticulum stress, dysregulated RNA transport and metabolism and DNA damage repair (Mead et al., 2022; Neumann et al., 2006).