VDAC1 and amyotrophic lateral sclerosis: The exact nature of the associated membrane is unclear but has been suggested to be endoplasmic reticulum, with further evidence suggesting a role in regulating mitochondrial morphology, through an association with outer mitochondrial membrane protein VDAC1, processes which have known relevance in the pathogenesis of ALS (Dafinca et al., 2021; Gao et al., 2020; Liu et al., 2009).