Furthermore, in the lysosomal storage disorder Gaucher disease, for which secreted CHIT1 is a key diagnostic marker (Hollak et al., 1994), the characteristically lipid‐laden macrophages show increases in the abundance of chemokine CCL18 and Glycoprotein nonmetastatic melanoma protein B (GPNMB) that are typically more indicative of alternatively activated microglia (Hüttenrauch et al., 2018; Kramer et al., 2016; Zigdon et al., 2015). This evidence concerns the gene GPNMB and lysosomal storage disease.