Ubiquitin carboxyl‐terminal hydrolase isozyme L1 (UCHL1; upregulated in ALS versus healthy controls) was proportional to disability progression rate (Pearson r = 0.53, FDR‐adjusted p = 0.003) and survival (Kaplan Meier log‐rank p = 0.013) but not independently in multivariate proportional hazards models. The gene discussed is UCHL1; the disease is amyotrophic lateral sclerosis.