Endoplasmic reticulum stress is thought to be an important early factor in cellular dysfunction in both sporadic and C9orf72 ALS, with a direct interaction between TDP‐43 and BiP also demonstrated (Dafinca et al., 2016, 2021; Feneberg et al., 2020; François‐Moutal et al., 2022; Pilotto et al., 2022; Sasaki, 2010). The gene discussed is HSPA5; the disease is amyotrophic lateral sclerosis.