Improving proteomic depth by immuno‐depletion of abundant proteins and strategies combining isobaric labelling with pre‐fractionation have been undertaken, yielding several promising candidate biomarkers including Ubiquitin carboxyl‐terminal hydrolase isozyme L1 (UCHL1) and Neuronal pentraxin‐2 (NPTX2; Collins et al., 2015; Oeckl et al., 2020; Oh et al., 2023) in CSF in ALS. This evidence concerns the gene UCHL1 and amyotrophic lateral sclerosis.