APOE and Alzheimer disease: While APOE ɛ2/3/4 status differed between the low and high AD-PRS groups (Table 1), these did not confound the AD-PRS genetic risk effects we observed, as the association was further present in the sub-sample of APOE ε3ε3 carriers (N = 13, t =  − 3.25, PFDR = 0.024).