Interestingly, a previous case–control EWAS comparing 36 female chronic headache patients to 35 female episodic headache patients found the two strongest associated loci were linked to brain-expressed genes (SH2D5 and NPTX2) that are involved in the regulation of synaptic plasticity [5], although these were not experiment-wide significant. Here, SH2D5 is linked to headache disorder.