The conditional Hdac4 deletions resulted in significant transcriptional dysregulation of genes involved in pain sensitivity, such as Calca and Trpv1, encoding Calcitonin Gene-Related Peptide 1 (CGRP) and Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) respectively—both also known to be involved in migraine [33, 34]. This evidence concerns the gene HDAC4 and migraine disorder.