CD274 and neoplasm: It is worth noting, however, that the corpus of literature referenced herein exclusively scrutinizes tumor-derived extracellular vesicular PD-L1, and while the significance of PD-L1 expression in bone marrow cells in the context of immunosuppression is undeniable, no investigations pertaining to extracellular vesicular PD-L1 emanating from bone marrow cells have graced the scientific discourse thus far.