On the other hand, proteins involved in mRNA-associated biological processes, such as mRNA splicing and transport (DDX39B, SRSF1, HNRNPA3, HNRNPA2B1, QKI, and FMR1), and nucleus response-associated processes, such as nucleosome assembly and chromosome condensation (H3-3A, H1-5, H1-4, H1-3, and H1–10), were found to be downregulated in the COVID-19 patient heart tissues, indicating that the ability of transcription in the COVID-19 patient heart tissues may be affected. The gene discussed is HNRNPA2B1; the disease is COVID-19.