As far as the 24-h post-infection upregulated pattern is concerned, the enrichment functions were associated with energy (through proteins such as NDUFA5 and ATP5ME, Fig. 2B), lipid or hepoxilin metabolism (through proteins such as GSTM1 and SMPD1, Fig. 2B), probably due to the stress response to cellular hypoxia and the energy supply in the primary infection. The gene discussed is SMPD1; the disease is infection.