Similarly, after their culture with ECs, IL30-overexpressing PCs showed a dramatic upregulation of a wide range of oncogenes, which included CCND2, EGR3, IGFBP5, KLK3, PDLIM4, PTGS1 and SHBG and a few tumor suppressors, such as GPX3, FOXO1, MAX and NKX3-1 (Fig. 6E, F). Here, SHBG is linked to neoplasm.