IL30 driven EC activation and inflammation is associated with the phosphorylation of a cascade of signaling proteins, which includes SRC, YES, STAT3, STAT6, RSK 1/2, C-JUN, AKT and, primarily CREB [42, 43], GSK-3α/β [44], HSP60 [45] and p53 [46] leading to endothelial dysfunction. Here, CREB1 is linked to endothelial dysfunction.