Moreover, immunohistochemical analysis confirmed, in vivo, overexpression of the aforementioned inflammation and cancer driver genes (IL12B, SHBG, TNFA, LGALS4) in IL30-overexpressing DU145 and PC3 tumors, compared to control tumors (Fig. 7C, Supplementary Fig. S8 and Supplementary Table S9). This evidence concerns the gene SHBG and cancer.