Endothelial phenotype remodeling, by contact with IL30-overexpressing PC, is also demonstrated by the upregulation of ITGAV, which contributes to EC proliferation and migration [55] and promotes PC progression [56, 57], and the Notch ligand JAG1, which is essential for blood vessel formation and maturation [58] and is associated with metastasis and poor disease-free survival of PC patients [59, 60]. Here, ITGAV is linked to pachyonychia congenita.