SHBG and pachyonychia congenita: Among the PC driver genes that were found upregulated in IL30 overexpressing PC cells, after coculture with ECs (Fig. 7A), genes coding for Galectin 4 (LGALS4), Gonadotropin Releasing Hormone 1 (GNRH1), and Sex Hormone Binding Globulin (SHBG) correlated with IL30 expression also in clinical PC samples, as assessed by bioinformatics of RNA-Seq data from the PCTA collection.