EDN1 and cancer: Reprogramming of the endothelial transcriptional profile, due to contact with IL30-overexpressing PC cells, feeds significant autocrine growth loops, which are mediated by typical endothelial growth factors, such as IGF1 [32], ANG [39], and EDN1 [26], or by immunoregulatory molecules, such as CXCL10, which in addition to its role in leukocytes recruitment, has demonstrated to fuel cancer stem cell proliferation [18] and, depending on the dose and signaling pathway involved, to exert angiostatic or angiogenic effects [53, 54], as we observed in this context.