Contact with the endothelium also fosters, in IL30-overexpressing cancer cells, a PC progression program as demonstrated by the dramatic upregulation of a wide range of PC driver genes, including BCL2, CCND2, EGR3, GNRH1, IGFBP5, IL6, KLK3, PTGS1, SHBG, SREBF1 and VEGFA, that largely overwhelm the expression of tumor suppressors FOXO1 [81], GPX3 [82], NKX3-1 [83], and PDLIM4 [84]. The gene discussed is IGFBP5; the disease is pachyonychia congenita.