IGF1, CXCL10, EDN1 and ANG cooperate substantially in mediating IL30-driven endothelial hyperproliferation and are most likely involved in IL30 driven in vivo angiogenesis, since IL30 overexpressing tumors developed after xenograft implantation of IL30-PC3 or IL30-DU145 cells, which have demonstrated overgrowth and metastatic behavior [15], showed a prosperous vascularity, hyperproliferation and strong expression of these angiogenesis regulators when compared to control tumors, as reported in ref 15 and confirmed by data on PC3 tumor xenografts (Supplementary Table S5, Fig. 4R, S, T). Here, EDN1 is linked to neoplasm.