Since in clinical PC samples cancer cells are in close contact with the endothelium, to assess whether the experimental findings have clinical relevance, we investigated in patient-derived PC samples the expression levels of IL30 along with that of immunoregulatory and PC driver genes, which were regulated in both IL30 overexpressing DU145, and PC3 cells after coculture with ECs when compared to wild type DU145, and PC3 cells, respectively, cocultured with ECs (Fig. 7A, B). Here, IL27 is linked to pachyonychia congenita.