Here, we investigate the reciprocal contact-dependent regulation of the angiogenic, immunoregulatory and oncogenic programs in PC and endothelial cells (ECs), respectively, and highlight the impact of PC-derived IL30 on the genotypic and phenotypic profiles of ECs, but also the feedback on PC gene expression programs of the EC response to the tumor expression of IL30. Here, IL27 is linked to neoplasm.