IL27 and pachyonychia congenita: We recently demonstrated that the immunoregulatory molecule, interleukin(IL)-30 (IL27/p28) [13], which is expressed as a membrane-anchored cytokine, by human PC cells, and in the microenvironment, by tumor-infiltrating immune cells, mainly macrophages and myeloid-derived suppressor cells (MDSCs) [14, 15], plays a critical role in PC onset and progression, by triggering a cascade of proinflammatory and oncogenic events, in association with the development of a robust vascular network [16, 17].