The AUC values were 0.65 in the model using age, sex, education duration, ApoE4, baseline cognition, and longitudinal cognitive rate [21], 0.72 in the model using age, sex, education duration, ApoE4, and neuropsychological tests (such as MMSE score, Alzheimer’s disease assessment scale, and logical memory II) [22], and 0.83 in the model using age, 10-word delayed recall, and ApoE4 [23]. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.