First, these EVs, expressing multiple EV-specific markers such as CD63, CD81, and ALIX and lacking deep cellular proteins, displayed a robust ability to suppress the release of IL-6 from LPS-stimulated mouse macrophages in vitro in a dose-dependent manner and to significantly dampen the cytokine storm in the hippocampus following an episode of status epilepticus [31]. Here, PDCD6IP is linked to status epilepticus.