Consistently, the immunohistochemical analysis results of ccRCC tumour tissue in nude mice showed that, compared with the scrambled group, the expression levels of CD56, β-catenin and c-Myc in the CD56-KO group were significantly decreased, while the expression level of SUFU was significantly increased (Fig. 3F). The gene discussed is SUFU; the disease is nonpapillary renal cell carcinoma.