In multivariable Cox analysis, the presence of CH, along with diffusing capacity for carbon monoxide < 60%, the rate of EGFR mutation, histologic type, and tumor stage, was a significant prognostic factor for OS in patients with advanced NSCLC who underwent adjuvant therapy (hazard ratio [HR] [95% confidence interval] = 1.56 [1.07–2.28], p = 0.020) (Table 2) (Fig. 4). This evidence concerns the gene EGFR and cyclic hematopoiesis.