ApoB (mediation proportion: 23.71%), total cholesterol (22.20%), type 2 diabetes (21.96%), fasting insulin (21.65%), SBP (21.53%), LDL-C (17.25%), appendicular lean mass (16.80%), grip strength (13.01%), triglycerides (11.21%), and 2-h glucose (10.7%) each mediated more than 10% of the total effect of birthweight on MI (Fig. 3A). This evidence concerns the gene INS and type 2 diabetes mellitus.