In MVMR, with adjustment for birthweight, each 1-unit increase in genetically determined education, household income, height, appendicular lean mass, and grip strength were associated with a 6-46% lower MI risk, whereas SBP, type 2 diabetes, fasting glucose, 2-h glucose, glycated hemoglobin A1c (HbA1c), fasting insulin, total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, apolipoprotein B (ApoB), Omega-6 fatty acids, and linoleic acid were causally associated with a 3-103% higher MI risk (Additional file 1: Table S7). The gene discussed is INS; the disease is type 2 diabetes mellitus.