The meta-analysis looking at the DEPs in VH between wet AMD patients and healthy controls was performed on five proteins (Fig. 5): Ig gamma − 1 chain C region (IGHG1, P01857), Ig kappa chain C region (IGKC, P01834), Ig lambda − 2 chain C regions (IGLC2, P0DOY2), PTGDS (P41222) and serotransferrin (TF, P02787). The gene discussed is IGHG1; the disease is age-related macular degeneration.