Next, THP-1 (KRAS-independent, STK33-independent), NOMO-1 (KRAS-dependent, STK33-dependent), and SKM-1 (KRAS-dependent, STK33-dependent) leukemia cell lines were used to compare the anticancer effect of Z29077885 to those of BRD-8899 and ML-281[13]. Here, KRAS is linked to leukemia.