In summary, our study was the first to show that rs62069863 in TRPV3 gene, rs2232016 in PRMT6 gene, rs1112718 in HHEX/EXOC6 gene, rs10460009 in LPIN2 gene and rs927316 in GLIS3 gene were susceptibility loci for GDM and were all significantly associated with blood glucose levels during pregnancy. The gene discussed is LPIN2; the disease is gestational diabetes.