In addition, Ca2+/MK IIα is linked to cAMP response element-binding protein (CREB) activation (Figs. 1–6), which in turn inversely correlates to the amygdala-induced anxiety-like behavior [257, also see 258–261] and altered CREB-BDNF signaling pathway relates to cognitive decline and Aβ toxicity in Alzheimer’s disease [260]. This evidence concerns the gene CREB1 and early-onset autosomal dominant Alzheimer disease.