Previous studies indicated that kana and kanji processings may occur in distinct brain regions, as evidenced by the occasional impairment of kana selectivity in cases of frontal or parietal lesions in Japanese amyotrophic lateral sclerosis (ALS) patients, being the predominant motor neuron disease characterized by the accumulation of TDP-43 [7]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.