Furthermore, ex vivo cultured granulocytes from FMF patients exhibit a unique phenotype with spontaneous release of high levels of IL-18, S100A12, MPO (myeloperoxidase), caspase-1, and proteinase [12], as well as activation quantified by spontaneous shedding of CD62L from the cell surface. The gene discussed is S100A12; the disease is familial Mediterranean fever.