IGF-1 can bind to the insulin receptor with reduced affinity compared to insulin11, promoting insulin sensitivity in muscles.57 In our previous studies, IGF-1 supplementation failed to affect the hyperglycemia during the first week of life and did not induce hypoglycemia.37,39 In this study, preterm pigs showed reduced glucose and insulin levels at PND19. This evidence concerns the gene INS and Hypoglycemia.