The more specific term 'cytokine signaling in immune system' (Reactome HSA-1280215) included 19 proteins (strength 0.51, FDR 0.001) listed here: CD4, BCL2, B2M, HLA-DRB1, LCK, NRAS, PSMB9, PLCG2 and SYK (all first level interactors for ≥ 10 other differentially regulated proteins), while TIMP1 (6), KPNA3 (4), NUP93 (4), PSMF1 (1), UBA3 (3), HLA-E (9), TRIM22 (2), MAPK9 (5), HLA-B (5) and IRF5 (4) also interact with multiple proteins (numbers of interacting proteins shown in brackets), giving weight to the association of immune system dysregulation in LC. Here, HLA-DRB1 is linked to laryngotracheoesophageal cleft.