The more specific term 'cytokine signaling in immune system' (Reactome HSA-1280215) included 19 proteins (strength 0.51, FDR 0.001) listed here: CD4, BCL2, B2M, HLA-DRB1, LCK, NRAS, PSMB9, PLCG2 and SYK (all first level interactors for ≥ 10 other differentially regulated proteins), while TIMP1 (6), KPNA3 (4), NUP93 (4), PSMF1 (1), UBA3 (3), HLA-E (9), TRIM22 (2), MAPK9 (5), HLA-B (5) and IRF5 (4) also interact with multiple proteins (numbers of interacting proteins shown in brackets), giving weight to the association of immune system dysregulation in LC. The gene discussed is SYK; the disease is laryngotracheoesophageal cleft.