Genes PRKCZ (Protein Kinase C Zeta), FGR (Src family protein), KDM4B, MPO, COL11A1, FUT4 (Fucosyltransferase IV), and APEH (acylpeptide hydrolase) are directly associated with tumor aggressiveness, growth, and migration, and invasiveness, resulting in poor clinical outcome in cancer patients41,46–50. This evidence concerns the gene KDM4B and neoplasm.