Additionally, methylation in PLCB3, MBP, ZNF156, PRKCZ, KDM4B, UHRF1, MLLT1, FLNB, and HLA-DRB5 showed both positive and negative associations with gene expression in different tissue-specific carcinomas, suggesting that the methylation and gene expression could be tissue specific. The gene discussed is UHRF1; the disease is carcinoma.