CD8A and neoplasm: Similarly, hiPSC-derived CAR-macrophages improved CD8 T-cell amplification and chemotaxis, and reduced the tumor-burden in multiple murine ovarian cancer models; even achieving lasting responses under some conditions34,36 (Fig. 3, red cue); although farther exploration of how CAR-mediated myeloid cell activation shapes adaptive tumor immunity will be necessary, since most current studies relied on co-cultured in vitro systems or murine mutants without functional lymphoid cells.