In addition, we combined bioinformatics analysis and qRT-PCR results to obtain five circRNA–miRNA–mRNA mechanistic axes that correlate negatively with HCC prognosis (hsa_circ_0091581/miR-1179/AP3B1, hsa_circ_0059730/miR-516a-5p/ADSL, hsa_circ_0059730/miR-378g/TRNP1, hsa_circ_0059730/miR-515-5p/MAPRE1, and hsa_circ_0091580/miR-1179/AP3B1). This evidence concerns the gene AP3B1 and hepatocellular carcinoma.