Moreover, Cao et al.30 verified that hsa_circ_0003410 promotes HCC progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis, Liu et al. found that EIF4A3-induced circTOLLIP promotes progression of HCC via the miR-516a-5p/PBX3/EMT pathway, and Wu et al.31 confirmed that methyltransferase-like 3-mediated m6A methylation of hsacirc_0058493 accelerates HCC progression by binding to YTH domain-containing protein 1. The gene discussed is CCL5; the disease is hepatocellular carcinoma.