ITGAE and ovarian carcinoma: Even though in ovarian cancer, particularly in HGSOC, immune infiltration by CD8+CD103+ CTLs has been associated with increased progression-free survival, recent findings indicate that a large portion of this population are positive for T-cell immunoglobulin and mucin-domain containing-3 (TIM3)20,21 and Lymphocyte Activation Gene-3 (LAG3)21,22 in epithelial ovarian cancer (EOC), suggesting they are prone to exhaustion and attenuated effector functions.