Immunohistochemistry for β-amyloid and phosphorylated tau demonstrated the presence of neuritic plaques and neurofibrillary tangles consistent with intermediate Alzheimer’s disease neuropathologic changes (Thal phase 5 of 5 for β-amyloid deposition, Braak and Braak stage IV of VI for neurofibrillary tangles, and CERAD frequent neuritic plaques: Intermediate Alzheimer’s disease Neuropathology Change A3, B2, C3). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.