huPBMC humanized mice model can rapidly reconstitute mature and activated human T-lymphocytes, but cannot successfully reconstitute the myeloid system including DCs, or present antigens.194 The anti-tumor effect of carbonic anhydrase 9 antibody was tested using allogeneic huPBMC in NOD/SCID/IL2Rγ (-/-) mice by transplanting a novel orthotopic renal cell carcinoma CDX and found that the antibody of this tumor-specific antigen inhibited tumor growth.196 Transplanted human PBMC mediates acute graft-versus-host disease and body weight loss. Here, CA9 is linked to neoplasm.