Low muscle radiodensity was associated with higher ISS (III vs. I/II) and R-ISS stages (III vs. I/II), older age (≥65 years), anemia (Hb < 10 g/dL), and renal failure (Cr ≥ 2 mg/dL) (Table 3). Here, GSTM1 is linked to Renal insufficiency.