Activation of necroptosis leads to robust induction of IL-8 expression and secretion.16 Elevated levels of IL-8 expression have been found in the monocytes from ALS patients which demonstrated a unique inflammation-related gene expression profile.20 Thus, the elevated levels of IL-8 in our study may be of monocytic origin. The gene discussed is CXCL8; the disease is amyotrophic lateral sclerosis.