Moreover, previous T2D studies performed in blood found differential methylation of the same genes as we identified in the Islet T2D case-control cohort (e.g., TXNIP, ABCG1, and HDAC4), but the specific sites identified in blood were different from the methylation sites identified in islets (Supplementary Data 1, 14)27–33. Here, ABCG1 is linked to type 2 diabetes mellitus.