Importantly, of sites reported by Dayeh et al. to have altered methylation in islets from T2D cases (q < 0.05 and Δβ ≥ 5%), we could replicate 813 sites with consistent differences between cases and controls (Supplementary Data 7), including sites annotated to CACNA1C, CDKN1A, GLP1R, HDAC4, HDAC7, IL6R, KCNQ1, PDE7B, and THADA (Supplementary Fig. 1a–i). Here, CACNA1C is linked to type 2 diabetes mellitus.