We found four sites, annotated to NKX6.2, SYNPO, RHOT1, and CABLES1, associated with a lower risk of incident T2D in EPIC-Potsdam (odds ratios <1; p < 0.05) and with lower methylation in islets from T2D cases versus controls (Table 2). Here, RHOT1 is linked to type 2 diabetes mellitus.