To evaluate the possibility of altered methylation in islets from T2D cases affecting TF binding, we combined our 31,806 T2D-associated methylation sites with DNA sequences bound by islet-specific TFs (FOXA2, MAFB, NKX2.2, NKX6.1, and PDX1)24. Here, NKX2-2 is linked to type 2 diabetes mellitus.