HDAC4 and type 2 diabetes mellitus: Moreover, previous T2D studies performed in blood found differential methylation of the same genes as we identified in the Islet T2D case-control cohort (e.g., TXNIP, ABCG1, and HDAC4), but the specific sites identified in blood were different from the methylation sites identified in islets (Supplementary Data 1, 14)27–33.