Islet RNA-seq data showed increased expression of NKX6.2 and SYNPO in T2D islets, where the methylation sites are in promoter regions, and decreased expression of RHOT1 and CABLES1 in T2D islets, where the methylation sites are in gene bodies (Supplementary Data 9, Figs. 2d and 3c, d). Here, NKX6-2 is linked to type 2 diabetes mellitus.