We also replicated data from our smaller islet case-control cohorts in this larger cohort, including differential methylation of CDKN1A, GLP1R, HDAC7, KCNQ1, PDE7B, and PDX1 in T2D islets, supporting the robustness of our data4,6. The gene discussed is KCNQ1; the disease is type 2 diabetes mellitus.