One example is SLC7A2, which encodes an amino acid transporter; an OCR ~ 1.5 kb upstream of the transcription start site (TSS) was found only in islets from T2D cases, and DNA methylation was lower in T2D islets (Supplementary Fig. 2a, Supplementary Data 8). This evidence concerns the gene SLC38A7 and type 2 diabetes mellitus.