Indeed, it has been reported that the expression of PFKP is increased in the glomeruli of patients with DKD, and PFKP activation ameliorates podocyte cytoskeletal remodeling in podocytes through regulation of F-1,6-BP levels and inhibition of the Ras homology A/Rho-associated kinase 1 (RhoA/ROCK1) pathway in vitro [42]. This evidence concerns the gene RHOA and diabetic kidney disease.