Tan and his team induced hepatic fibrosis in mice by injecting CCl4, and they found expression upregulation of Fas, FasL, caspase-3, α-smooth muscle actin (SMA), Col-I and Col-IV, suggesting that hepatocyte apoptosis regulated by Fas/FasL was involved in in hepatic fibrosis [34]. This evidence concerns the gene CASP3 and Hepatic fibrosis.