Su and his colleagues found that hepatocyte-specific TAK1 deficiency led to an imbalance of iron ions in hepatocytes, resulting in ferroptosis, which led to oxidative stress, activation of the macrophage STING signaling pathway and exacerbation of hepatic fibrosis, all of which were markedly attenuated by ferratine-1 treatment, suggesting that targeting ferroptosis of hepatocytes could be useful in the treatment of liver injury and hepatic fibrosis [86]. The gene discussed is STING1; the disease is Hepatic fibrosis.