A recent study by Cao and his team showed that E7046, the specific prostaglandin E2 (PGE2) and its receptor EP4 antagonist, significantly suppressed M2 macrophage-mediated autophagy in HSCs and ameliorated hepatic fibrosis caused by NAFLD in mice, confirming that PGE2/EP4 enhanced autophagy in HSCs via the Erk pathway to cause fibrosis [49]. Here, PTGER4 is linked to Hepatic fibrosis.