The effect on pathological tumor-induced angiogenesis occurred in the absence or presence of tumor-derived Angptl4, which in turn has been described to have both pro- or anti-angiogenic effects47, indicating that endothelial ANGPTL4 facilitates pathological angiogenesis cell-autonomously, since reduced tumor angiogenesis observed in Angptl4iΔEC mice could not be compensated by ANGPTL4 derived from cancer cells that also express and produce ANGPTL44,31,47. The gene discussed is ANGPTL4; the disease is cancer.