These results were comparable to those obtained when LLC expressing Angptl4 were implanted in WT or Angptl4iΔEC mice (Fig. 2a and b), and suggest a cell-autonomous role of endothelial ANGPTL4 in regulating tumor-induced angiogenesis, since in the absence of cancer cell-derived ANGPTL4, Angptl4iΔEC mice still developed smaller tumors compared to WT mice. Here, ANGPTL4 is linked to cancer.