ANGPTL4 and hypoxia: To further assess whether the reduced glycolytic phenotype observed upon ANGPTL4 KD was, at least in part, dependent on its secretion from ECs, we incubated control or ANGPTL4 KD ECs in conditioned media (CM) enriched (NS-Hypoxia CM) or depleted of ANGPTL4 (siANGPTL4-Hypoxia CM) (Supplementary Fig. 6g).