CASP3 and cancer: Our results showed that apoptosis was induced in human non-small cell lung cancer H1975 cells treated with compound 16 via regulating apoptosis-related proteins, including Bax, Bcl-2, Akt, and Cyt C. Many previous studies have reported that anti-cancer agents induced apoptosis via the activation of caspases, including caspase-3, -8, and -935,.36