The top ten signaling pathways included Proteoglycans in cancer (hsa05205), PI3K − Akt signaling pathway (hsa04151), lipid and atherosclerosis (hsa05417), Kaposi sarcoma−associated herpesvirus infection (hsa05167), human T − cell leukemia virus 1 infection (hsa05166), hepatitis B (hsa05161), endocrine resistance (hsa01522), chemical carcinogenesis‐receptor activation (hsa05207), relaxin signaling pathway (hsa04926) and Ras signaling pathway (hsa04014) (Figure 5). The gene discussed is PIK3CA; the disease is atherosclerosis.