We studied the presence of IL-1B for the diagnosis of periodontitis and gingivitis that coincided with the study conducted by Sohail et al in which early diagnosis of oral cancer had been identified by the detection of IL-8 innaswarusers in a similar population.23The use of saliva to evaluate both oral and systemic health had also been described; however, patients with systemic disorders were also included in the previous studies.24Our study found that patients with gingivitis and periodontitis exhibited deeper probing depths than healthy controls.25, 26. The gene discussed is CXCL8; the disease is lip and oral cavity carcinoma.