A total of 139 proteins and phosphoproteins, representing key cancer signaling pathways including DNA repair deficiency (DRD), cell cycle/proliferation, PI3K/AKT/mTOR signaling, receptor tyrosine kinases (RTKs), immune and survival signaling were quantitatively measured by RPPA-based protein expression and signaling activation analysis (Figure 1C). This evidence concerns the gene PIK3CA and dystonia 5.