Furthermore, investigations into patients with precocious puberty revealed the presence of activating mutations in the genes expressing kiss1 and the kiss1 receptor (Teles et al. 2008, Silveira et al. 2010) while inactivating mutations in the genes encoding the kiss1 receptor led to hypogonadotropic hypogonadism (De Roux et al. 2003, Seminara et al. 2003). This evidence concerns the gene KISS1R and hypogonadotropic hypogonadism.