In conclusion, by bioinformatics analysis and in vitro experimental validation, our research found that cuproptosis possibly be the potential common pathogenesis of three kinds of primary cardiomyopathy, and FDX1, MAP2K1 and SLC31A1 possibly be prospective markers for the diagnosis and molecular subtype identification of primary cardiomyopathy. This evidence concerns the gene SLC31A1 and intrinsic cardiomyopathy.