While human data on microglial CF is limited, studies have shown that (where detected) CF is expressed predominantly in myeloid cells (Zhang et al., 2016; Mathys et al., 2019; Schirmer et al., 2019; Srinivasan et al., 2020) and identified CF expression in microglia around plaques in AD (Ofengeim et al., 2017) and CST7 enrichment in AD-associated microglia clusters by single nucleus RNA sequencing (snRNASeq) (Gerrits et al., 2021). This evidence concerns the gene CFTR and Alzheimer disease.