For example, microglia lacking TAM receptors Axl and Mer fail to take up Aβ which leads to an overall decrease in dense-core plaque formation (Huang et al., 2021), microglia can ‘seed’ plaques from disease tissue into engrafted, non-affected regions (d’Errico et al., 2022), and either genetic or pharmacological depletion of microglia leads to a reduction in plaque burden/intensity accompanied by increase in cerebral amyloid angiopathy (Spangenberg et al., 2019; Kiani Shabestari et al., 2022) perhaps through redistributing Aβ. This evidence concerns the gene AXL and cerebral amyloid angiopathy.