Some studies have suggested CF may play a protective role in a demyelination model by inhibiting cathepsin C (Liang et al., 2016) or negatively regulating microglial phagocytosis (Kang et al., 2018; Popescu et al., 2023) but the possible disease-modifying role of Cst7/CF in amyloid-driven neurodegenerative disease is unknown. This evidence concerns the gene CST7 and neurodegenerative disease.