Notably, transplantation of rADSCsCHIP-WT in the SHR model we observed an increased expression of IGF1 and IGFBP3 and further supporting the importance of CHIP overexpressing stem cell-based therapies in aging and hypertension; therefore, insulin/IGF1 plays an important role in development and metabolism throughout life, from ontogeny to advanced age. Here, STUB1 is linked to hypertensive disorder.