VHL and renal cell carcinoma: In the primary RCC tumor cases, the most commonly affected genes were, by frequency, VHL (von Hippel-Lindau tumor suppressor), PBRM1 (polybromo 1), TTN (titin), MUC16 (mucin 16, cell surface associated), SETD2 (SET domain containing 2, histone lysine methyltransferase), BAP1 (BRCA1 associated protein 1), LRP2 (LDL receptor related protein 2), DST (dystonin), KMT2C (lysine methyltransferase 2C), and TP53 (tumor protein p53) [28].