In PTC tissue, higher transcriptional activity of TGFβ1 gene and lower transcriptional activity of TGFβRII and TGFβRIII genes in comparison with benign tissues suggests its importance of this cytokine and its receptors in pathogenesis of cancer development [5] and are essentially similar to our observations in patients with RCC. The gene discussed is TGFB1; the disease is renal cell carcinoma.