Although clusters from ER+ breast and liver cancers were largely correlated by cancer type (Fig. 4C, cluster 5 and 9) due to specific expression of ER-responsive genes and metabolic pathways, respectively (Supplementary Fig. 11A), we found several recurring clusters across four pan-cancers including invasion [1], proliferation/MYC [2] and inflammation [4] (Fig. 4C). Here, MYC is linked to liver cancer.