However, we observed a significant reduction in the distribution of HK-CPs in cancer cell lines (86.05% of HK-CPs, n = 8,354), where 1,354 HK-CPs did not fulfill the given housekeeping threshold; Supplementary Table S3 contains the list of HK-CPs that did not satisfy the threshold ranked by their ascending percentage of cancer cells they are found active on. Here, CAD is linked to cancer.