To explore the contribution of METTL16 to colorectal carcinogenesis, we utilized short‐hairpin RNA (shRNA)‐mediated knockdown to silence METTL16 expression in HCT116 (CRC cell line), SW620 (CRC cell line) and HeLa cells (cervical cancer cell line) (Figure S1B). Here, METTL16 is linked to colorectal carcinoma.