Three classes of PI3Ks exist, but only class I PI3Ks have been associated with carcinogenesis and BLCA.[29] The class IA PI3Ks are heterodimers, including p110 catalytic subunits (p110α/PIK3CA, p110β/PIK3CB, and p110δ/PIK3CD) and p85 regulatory subunits (p85α/PIK3R1 and p85β/PIK3R2).[29, 30] We revealed that G3BP1 and SLU7 jointly bind to the mRNAs of most class IA PI3Ks, stabilize the mRNAs, and enhance their translation. This evidence concerns the gene PIK3CB and bladder transitional cell carcinoma.