These findings are surprising, as previous studies have revealed that G3BP1 promotes mRNA degradation by binding to UPF1 and that G3BP1 binds to the rG4 structure to maintain mRNA stability but inhibit translation.[22, 31] This discrepancy may be because G3BP1 coordinates with SLU7 to form a complex with PABPC1 and eIF4G1 to stabilize the closed‐loop structure of the mRNAs of class IA PI3Ks,[10, 23] indicating the new role of SLU7 in sustaining PI3K/Akt signaling to downregulate MHC‐I in BLCA cells. The gene discussed is UPF1; the disease is bladder transitional cell carcinoma.