This study identified an interaction between SLU7 and G3BP1 in BLCA cells, which is consistent with the finding of a previous MS analysis conducted in hepatoma cells.[33] The SLU7 interactome analysis revealed the presence of cytoplasmic proteins[33] such as G3BP1 as well as other proteins responsible for preserving the closed‐loop structure of mRNAs (e.g., PABPCs, eIF3s, and eIF4s).[10, 23] Consequently, Slu7 may enhance Akt activation in the mouse liver[14b] through our proposed mechanism, although further investigation is warranted to validate this hypothesis. This evidence concerns the gene G3BP1 and hepatocellular carcinoma.