Three classes of PI3Ks exist, but only class I PI3Ks have been associated with carcinogenesis and BLCA.[29] The class IA PI3Ks are heterodimers, including p110 catalytic subunits (p110α/PIK3CA, p110β/PIK3CB, and p110δ/PIK3CD) and p85 regulatory subunits (p85α/PIK3R1 and p85β/PIK3R2).[29, 30] We revealed that G3BP1 and SLU7 jointly bind to the mRNAs of most class IA PI3Ks, stabilize the mRNAs, and enhance their translation. The gene discussed is PIK3CA; the disease is bladder transitional cell carcinoma.