PIK3CA and neoplasm: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and gene set enrichment analysis (GSEA) demonstrated that G3BP1 knockdown inhibited the PI3K/Akt signaling pathway (Figure S2, Supporting Information; Figure 2A), which is known to repress tumor immunogenicity by downregulating MHC‐I.[21] Indeed, G3BP1 knockdown decreased p‐AktThr308 and p‐AktSer473 expression (PI3K effectors), but not total Akt expression, in UMUC3, T24, and MB49 cells (Figure 2B–D).