The potential pathogenesis of cardiovascular diseases combined with depression includes HPA axis disorder, inflammation, genetic factors, autonomic nervous dysfunction, 5-HT disorder, microRNA disorder, Omega-3 polyunsaturated fatty acid disorder, intestinal flora disorder, etc. In addition, corticosterone, 5-HT, Omega-3 fatty acids, CRP, IL-6, miR-132, miR-1-3p, and other substances may play an intermediate role in the physiological and pathological process of cardiovascular diseases complicated with depression. The gene discussed is IL6; the disease is major depressive disorder.