NOS1 and major depressive disorder: Results from a study in the Department of Cardiology at the First People's Hospital in Jining, China, in which peripheral blood samples were collected from 865 CAD patients, suggest that cardiovascular patients carrying the miR-146a rs2910164 C allele have a reduced risk of depression, an association that may be attributed to its ability to disrupt miR-146a expression, thereby increasing the expression of its target gene, NOS1 (78).