Based on a conservative neoplasm penetrance estimate of 10% in individuals aged 50-60 years with germline DICER1 variants [22] and higher penetrance in females than males, the VCEP determined that an observation of 10 or more unrelated females, who have reached 50 years of age without a tumor diagnosis, should qualify for BS2_Supporting, provided that the ratio of BS2-eligible females to PS4-eligible probands is equal to or greater than 10 : 1. Here, DICER1 is linked to neoplasm.