DICER1 and Cystic Nephroma: Studies of pleuropulmonary blastoma [24] and pituitary blastoma [29] suggest greater than 80% specificity for an underlying pathogenic germline DICER1 variant, while cystic nephroma [35] and Sertoli-Leydig cell tumors and gynandroblastoma [36] appear to fall in the 60-80% range.