In recessive model (OR=1.3, 95% CI=1.2–1.64, P=0.03) and overdominant model (OR=1.50, 95% CI=1.14–1.97, P=0.002), MMP3 -1612 5A/6A was correlated to susceptibility of CAD. This evidence concerns the gene MMP3 and coronary artery disorder.