The study evaluated the effectiveness of a polyphenol fraction from Cinnamomum zeylanicum bark (CPP) in various animal models of inflammation and arthritis, showcasing a dose-dependent reduction in paw swelling, reversal of weight loss in induced edema, and a significant decrease in TNF-α levels without causing gastric issues. These findings suggest that CPP exhibits strong potential as an anti-rheumatic agent with disease-modifying properties, demonstrating notable action in alleviating inflammation and arthritis in animal models. This evidence concerns the gene TNF and arthritic joint disease.